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Aggregated data indicated that patients treated with tirzepatide had lower risk of nasopharyngitis comparing with placebo (OR=0.71, 95%CI:0.50 to 0.90, p=0.005, Supplementary Figure S6D )

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The practical implication for research protocols is that retatrutide introduces an additional signaling pathway linked to energy expenditure and hepatic substrate mobilization in preclinical models

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