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Given the proposed critical role of metabolic alterations, particularly the accumulation of lipid droplets within cardiomyocytes, in driving diastolic dysfunction and HFpEF 56,57 , we examined this in the ZSF1 obese rat model

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Consequently, GLP-1R-induced neuroprotection may be mediated by its effects on cortical arterioles as well as ameliorated perfusion of the peri-infarct areas in the brain

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This may occur as we age, lose weight, or simply as a result of genetics