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The synergistic combination outperformed semaglutide in head-to-head trials, with average weight loss reaching 2022% of body weight

Semaglutide is associated with some similar side effects such as stomach aches and dizziness

Based on articles retrieved from PubMed, a 2022 systematic review and meta-analysis in Pharmacological Research examining 25 studies found berberine improved markers of kidney function including blood urea nitrogen (BUN), serum creatinine, and proteinuria in models of diabetic nephropathy
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