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However, in patients with T2D, GIP/GLP-1R dual agonists provide pharmacological concentration levels of GLP-1 and GIP, adding a synergistic effect and producing robust stimulation of insulin secretion

Crucially, we also differentiated between short-acting GLP-1 RAs, such as exenatide and lixisenatide, which have immediate postprandial effects

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Furthermore, the GLP-1R G-protein-biased agonist dosed at 1 or 10 g kg 1 significantly decreased ad libitum -fed blood glucose levels when compared with vehicle control whereas Ex4 showed efficacy only at the highest dose tested (Fig

doi: 10.1038/s41598-021-88612-x Liang L, Su X, Guan Y, Wu B, Zhang X, Nian X