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however, the precise pathophysiological mechanisms underlying this association remain unclear

glucose impairs this feedback mechanism, and the macula densa is exposed to lowered sodium concentrations, despite increased GFR, leading to the impairment of TGF signaling with a consequent increase in blood flow into the glomerulus

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BMC Res Notes 9:60 Diakogiannaki E, Gribble FM, Reimann F (2012) Nutrient detection by incretin hormone secreting cells

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