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2008) and mice with LAD coronary artery occlusion (Noyan-Ashraf et al
Tirzepatide has established itself as highly effective, with the 15 mg dose achieving 22.5% weight loss (95% CI, 23.3 to 21.7), representing a reduction of 23.6 kg (52.0 lb) in phase 3 obesity trials [73,78]
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Hypertonic chyme is detected by duodenal osmoreceptors and gastric emptying is slowed [51, 52]
