glp 1 drugs for perimenopause Let's talk about GLP-1 medications in the context of and menopause, because this is where the conversation most often gets flattened into something it is not. This is not about vanity GLP-1 medications are rapidly expanding

GLP-1 medications have generally been well-tolerated for long-term use, though they may have mild to moderate side effects such as nausea, vomiting, diarrhea, abdominal discomfort, or occasional constipation

Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure

[DOI] [Google Scholar] 38.Kwan AY, Maldonado JM, Wang H, Rasouli N, Wilding J

doi: 10.1016/j.eclinm.2025.103680

Final percent BMI reduction was 5.1% for GLP-1RA and 0.59% for metformin, with corresponding z-score decreases of 0.02 and 0.01, respectively