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The effect of GLP- 1 together with GIP on food intake, body weight, and locomotor activity was determined following intracerebroventricular (ICV) administration of GLP- 1 and/or GIP in mice

The benefit of split dosing is improved tolerability and more consistent appetite control, which may indirectly support better adherence and outcomes

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Rare but serious adverse effects require awareness: Pancreatitis (inflammation of the pancreas): severe, persistent abdominal pain radiating to the back warrants immediate medical assessment Gallbladder disease : rapid weight loss increases gallstone risk

Serious complications, such as pancreatitis, gallbladder problems, and kidney concerns, have been reported, though they are less common