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Scott Butsch, director of obesity medicine at Cleveland Clinics Bariatric and Metabolic Institute

& Gause-Nilsson, I

Several mechanisms may contribute to tiredness on tirzepatide

While both regulate blood sugar and reduce appetite, their mechanisms and origins set them apart
Retatrutide reduces appetite but does not eliminate the impact of calorie-dense food choices, alcohol consumption, poor sleep, or chronic stress, all of which can counteract the drug's effects
