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Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)

PMID: 1326760

10.1111/adb.12295 73 VallofD.VestlundJ.JerlhagE

Eli Lilly, the pharmaceutical company that makes Zepbound, blames the lack of coverage on the stigma of obesity

T Cell Regulatory Activities of DPP4 DPP4/CD26 is a non-lineage-specific antigen, although it is upregulated upon T cell activation