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Linagliptin lowered plasma glucose levels significantly at 30, 60, 90 and 120-minute during OGTT in high GLP-1 group ( Figures 2A, B )
In rats, feeding activity and food intake decreased following intracerebroventricular injection of GLP-1, an effect counteracted by co-administration of a GLP-1 receptor antagonist (71, 72), suggesting central GLP-1 as a potent inhibitor of feeding
American Diabetes Association Annual Meeting 2011 Poster 1029
