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Description
In the heart, validated studies find the receptor concentrated in the sinoatrial node, which explains the modest increase in heart rate, and in atrial myocytes, where it stimulates the release of atrial natriuretic peptide
Rder, P

Vigorous shaking creates foam, which introduces air and can damage the peptide through mechanical stress
Bikou A, Dermiki-Gkana F, Penteris M, Constantinides TK, Kontogiorgis C
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UK product information includes warnings about thyroid C-cell tumours observed in rodent studies, though this is not a formal contraindication in the UK as it is in some other countries
