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Non high density lipoprotein cholesterol fell by 53.4 percentage points relative to placebo, and apolipoprotein B declined by 50.3 percentage points
In preclinical models, the tirzepatide peptide is investigated to understand how dual incretin receptor agonism influences glucose homeostasis , insulin secretion , glucagon modulation , gastric motility , and satiety signaling in controlled experimental systems
For that reason, many experts classify tirzepatide as a dual GIP and GLP-1 receptor agonist rather than simply a GLP-1 medication
These distinct mechanisms explain why some patients consider dual therapy after plateauing on a single drug
