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Bias in meta-analysis and funnel plot asymmetry

A 2025 study published in JAMA Network Open found that most patients with obesity discontinue GLP-1 therapy within a year, particularly those without type 2 diabetes 1

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321 Genetic ablation of GIPR in leptin-deficient obese ( ob/ob ) mice was shown to ameliorate insulin insensitivity and obesity by increasing energy expenditure without significantly affecting insulin secretion

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