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The combination reduces the willpower typically required to sustain IF alone, particularly in weeks 2-4 when hunger adaptation lags behind behavioral change

Obesity can lead to insulin resistance, hypertension, and dyslipidemia, is associated with complications such as type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease, and reduces life expectancy

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Demand has outstripped manufacturing capacity at various points, leading to periodic shortages

Lund et al., 2014)