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The pattern typically looks like this: diarrhea appears or worsens within first few days after a dose increase, lasts for several days to a couple of weeks, and then settles as body adjusts

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A similar profile was observed for IP 1 accumulation with 4-fold lower potency for tirzepatide than GIP(1-42) (Figure 1B

It is usually mild, but it should be monitored, especially in people with heart disease

Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women