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doi: 10.1093/jn/131.3.709 212 RoccaASBrubakerPL
People who found a single GLP-1 drug intolerable at its top dose sometimes find the two-pathway approach easier to live with, precisely because neither compound is being pushed to its limit
The concurrent engagement of all three receptors is hypothesised to produce complementary metabolic effects in pre-clinical models: GLP-1R activation is associated with glucose regulation and appetite modulation, GIPR activation with potentiation of GLP-1mediated responses, and GcgR activation with energy expenditure and hepatic lipid metabolism in laboratory settings
Writing in the Canadian Journal of Anesthesia, they called for the drug to be stopped for even longer about three weeks before sedation
Others catch a break with retatrutide after all else weight loss-wise has failed
