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By activating GLP-1 receptors in the brain's appetite centers, semaglutide promotes satiety and reduces food intake

You still need to follow your labs

Typical timeline: Weeks 04 : Initial appetite suppression and modest weight loss, primarily fluid and glycogen Months 26 : Progressive weight loss with measurable reductions in waist circumference Months 612 : Continued but often slower weight loss, with maximum effect typically achieved by 1218 months Beyond 12 months : Weight maintenance phase

Bioelectrical impedance scales provide rough body fat estimates, though accuracy limitations exist

Fourth - and most time-sensitive: the FDA published a proposed rule on April 30, 2026 proposing to exclude semaglutide and tirzepatide from the 503B Bulks List, with a public comment period closing June 29, 2026