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Description
However, it is rapidly degraded by the DPP-4 enzyme, giving it a one-two minute half-life
Aim for 2.5 to 3.5 liters daily, with the higher end recommended during dose escalation when gastrointestinal side effects are most intense
Obesity itself promotes chronic low-grade inflammation through adipose tissue secretion of inflammatory cytokines
The clinical trial data provides specific frequency information that helps set realistic expectations
In a prospective open-label pilot study by Krajnc et al., patients had chronic IIH under treatment (some had persistent papilledema ~ 70% at baseline) [27]
