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There is a reasonable body of literature suggesting that even a 5% reduction in body weight correlates with meaningful changes in pain and function in people with OA

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The Phase 3 study could result in 25 to 30% mean weight loss

Both the potentiation of GLP-1 effects on body weight by estrogen, as well as the more robust food motivated behavior suppression achieved by GLP-1R activation in females may translate to higher efficacy of GLP-1 analogs in patients

FDA informational resources addressing GLP-1 medications and the regulatory status of compounded formulations
