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Kraus et al., 2007), and increases coupling between gastric myoelectric activity of the stomach and brain signals (Mller et al., 2022), which is in line with findings on vagal signaling derived with invasive methods in rodents (Cao et al., 2022

Diet tweaks that actually work To reduce nausea, GERD, and indigestion while on GLP-1s: Prefer smaller, lighter meals instead of heavy thalis or buffets Shift the plate so at least one-third to half comes from protein sources like dals, chana, rajma, soy products, paneer, curd, milk, sprouts, nuts, and seeds Choose steamed, grilled, sauted, or home-cooked dishes over deep-fried snacks and heavy gravies Limit very spicy, oily street food, especially in the first months For diarrhoea or loose motions, simple curd, buttermilk, and homemade ORS can help support gut health and hydration

Many individuals use standard over-the-counter supplements successfully

Participants in trials like STEP 1 tend to have extreme obesity (average BMI 38) and receive extensive support (including regular lifestyle counseling (source))

GLP1 medications produce the kind of significant, sustained weight loss (15 to 25 percent of body weight in clinical trials) that was previously achievable only through bariatric surgery