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Some GLP-1 medications are available as oral tablets, which dont cause the injection site reactions common to injectable GLP-1s

Alternatively, some patients separate the medications by taking levothyroxine at bedtime (2 hours after dinner) and semaglutide with their first meal the next day

ACG Clinical Guideline: Management of Irritable Bowel Syndrome

Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: An updated systematic review and meta-analysis including the latest SURMOUNT-2 trial