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The buzz surrounding GLP-1s keeps getting louder, and for good reason: The medications are highly effective at treating type 2 diabetes and obesity , and are also linked to improved blood pressure and protection against heart disease

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However, indirect factors such as gastrointestinal discomfort, blood sugar fluctuations, or rapid dietary changes may contribute to mood symptoms in some individuals

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To test this, we used doxycycline-inducible leptin transgenic mice that ectopically produced leptin from adipocytes to maintain circulating leptin levels during the period of liraglutide injection