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Thus, in overweight/obese women with PCOS, combination treatment is more effective than metformin alone by improving insulin sensitivity, with tolerable short-term side effects (201)

LeyREBckhedFTurnbaughPLozuponeCAKnightRDGordonJI

Metformin transporter pharmacogenomics: insights into drug disposition-where are we now
Protein intake also stimulates GLP-1 secretion, with studies suggesting that higher-protein meals elicit greater incretin responses compared to carbohydrate-predominant meals

Although the American Diabetes Association recommends metformin treatment as a first-line therapy, metformin treatment alone is insufficient to achieve target blood glucose level in most patients1)
