fda warning letters compounding semaglutide september 2025 How GLP-1s Broke Healthcare Distribution Why the FDA Issued 30
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Other GLP-1 Agonists Exenatide: The EXSCEL trial (2017) showed a non-significant 9% MACE reduction (HR 0.91, 95% CI 0.831.00) in 14,752 T2DM patients, suggesting modest cardiovascular benefits [17]

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In rats, administration of GLP-1R agonists into the hippocampus further prevented impairment of spatial learning and memory induced by central administration of amyloid (A), a protein considered to play a causative role in impairment of learning and memory in Alzheimer disease [832,833]

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Gastrointestinal (GI) side effects, such as sulfur burps, diarrhea, and nausea, are relatively common in people who take the drug