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Perhaps hypersensitivity to it, even when the classical target organs of insulin, such as muscle and fat, show resistance to its action.68 Insulin prevents ovulation both by direct involvement of follicular development and by the indirect increase in intra-ovarian androgen levels or alteration of gonadotropin secretion

Other reasons to contact your provider include: Weight loss that significantly exceeds your prescribed treatment plan Cold sensations accompanied by sweating, tremor, or confusion (possible hypoglycemia, especially if taking insulin or sulfonylureas) Persistent fatigue with pallor or weakness (possible anemia) Severe or persistent symptoms that significantly impact quality of life or do not improve with conservative measures Your healthcare provider can assess whether symptoms represent expected physiological adaptation, require investigation for alternative causes (including blood tests for thyroid function, complete blood count, iron studies, or vitamin B12 levels), or indicate a need for medication adjustment

For most patients, standard-dose semaglutide or tirzepatide is more likely to produce faster and more noticeable weight loss because the dose strategy is designed to reach stronger appetite-suppressing levels over time