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Persistent nausea that interferes with hydration, nutrition, or daily function should be discussed with a healthcare professional rather than assumed to be a normal adjustment symptom

8.1 Regulatory expectations and evidence standards Regulatory agencies increasingly emphasize mechanism-anchored development supported by robust pharmacodynamic biomarkers and clinically meaningful endpoints ( A recurring integrity issue in peptide development has been premature extrapolation from animal models to humans
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, Meier, J
