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The main downside was gastrointestinal side effects, mostly nausea

Molecular formula, molecular weight, substance identifier (SID), and CAS number for semaglutide are given

These medications have been game-changers for weight loss and diabetes management, but as more people use them, doctors and dentists are noticing a new issue: changes in oral health
doi: 10.1126/SCIENCE.AAU2277

This effect directly opposes Wegovy's appetite-suppressing action, potentially reducing the caloric deficit necessary for weight loss