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Mutations in genes such as PNPLA3 or adiponutrin (involved in remodeling of hepatic fatty acids), 29 transmembrane 6 superfamily member 2 (TM6SF2) (involved in lipidation of VLDL in a pre-Golgi compartment of liver), 30 membrane-bound O-acyl transferase domain-containing protein 7 (involved in phospholipid remodeling), 31 and glucokinase regulatory protein (regulator of hepatic DNL) 32 increase the risk of developing MAFLD

On the one hand, the GM can be directly or indirectly involved in the regulation of bone mass through the regulation of host metabolism, calcium absorption, hormone levels, and the immune system

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