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Keywords: Obesity, Diabetes, GLP-1 receptor agonist, Depression, Binge-eating disorder, Qualitative Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of drugs developed initially for treatment of type 2 diabetes (T2D) and then obesity, by mimicking the incretin effect which includes glucose-dependent increased insulin secretion and improved glycaemic control, and inducing weight loss in a dose-dependent manner [1]

Choose an injection site as recommended, usually the abdomen or thigh, avoiding areas that are red, swollen, or irritated

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For example, a patient taking once-daily long-acting (basal) insulin and starting a weekly GLP-1RA could be instructed after the second injection of dulaglutide/ semaglutide, every time your fasting glucose level is below [target] mmol/L, reduce your [insulin brand] insulin dose by [10% of dose] units