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Chronic hyperglycemia is responsible for many complications, including cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), eye disease, unintentional weight loss (due to metabolism of fat and muscle, as cells do not have access to glucose to metabolize), and diabetic ketoacidosis

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The GIP receptor activation appears to enhance insulin sensitivity and may influence fat metabolism and energy expenditure, though the precise mechanisms continue to be investigated

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The advantage is that the doctors and the team can monitor symptoms and adjust the program responsibly