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GLP-1 receptor agonists slow gastric emptying and alter digestive timing throughout the gastrointestinal tract

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Interestingly, like BETP, compound 2 interacts with cysteine 347 6.36 via covalent modification at the cytoplasmic side of GLP-1R, consistent with our previous observation that an intact ECD is required for the activity of BETP and compound 2 (ref

Sources: GLP-1 medications explained: Benefits, risks, and how they work | Baylor Scott & White Health GLP-1 receptor agonists and sarcopenia: Weight loss at a cost