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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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Basal phosphorylation was detected in wild-type receptors under unstimulated conditions, suggesting dynamic cycling between phosphorylated and unphosphorylated states

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Take one capsule once daily WITH food that contains fat