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Semaglutide GLP-1 injections for weight loss are not recommended for use on patients who also have been diagnosed with type 1 diabetes, decreased kidney function or kidney disease, medullary thyroid cancer, or disease of the gallbladder

In this Article we use a set of 125 experimentally characterized glucagon and GLP-1 peptide analogues to train models that capture the relationship between peptide sequence and agonism or receptor activation at both the GCGR and GLP-1R

Clinical trials show dramatic results, making these medications a powerful tool in the fight against obesity

This synergy is why some physicians recommend dual-peptide protocols for patients seeking both weight loss and body composition improvement

doi: 10.1016/j.cmet.2018.04.008