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Carpi, M

Adherence differs significantly between these two formats: forgetting a weekly injection typically results in catching up the following week, but missing a daily oral dose means you skip that day's medication entirely

Semaglutide-induced weight loss accompanied by the reduction in fat and lean mass in ob/ob mice Semaglutide intervention has previously been associated with concurrent reductions in both fat and lean mass in humans and rodent models of obesity (2224)

This may make maintaining weight loss after gastric bypass more difficult over time

At the same time, it is important to acknowledge the limitations of pivotal trials such as STEP and SELECT, whose generalisability is constrained by relatively short follow-up, notable dropout rates, and the predominance of Western cohorts