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The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)

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These could signal a more serious condition that needs medical evaluation

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These effects are typically most pronounced during treatment initiation and dose escalation, often improving over several weeks