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Materials and methods The effects of long-term exposures to tirzepatide, a novel dual GIP/GLP-1 receptor agonist, on neurotoxicity and behavioral changes in the D-galactose/aluminium chloride (D-gal/AlCl3)-induced rats' AD-like pathological model were evaluated

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After application of 1 M isoprenaline (to stimulate -adrenoceptors) or 1 M serotonin (to stimulate 5-HT4-serotonin receptors) or 1 M histamine (to stimulate H2-histamine receptors) or 10 M fenoldopam (to stimulate D1-dopamine receptors) or 100 nM semaglutide (to stimulate glucagon-like-peptide-1 receptors) or 100 nM gastric inhibitory peptide (to stimulate the gastric inhibitory peptide receptors) additionally applied 1 M muscarine reduced FOC

The GLP-1 RESET Log: An essential tool for recording important health data when taking GLP-1 medication