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Animal studies have shown concerns like reduced fetal growth, developmental abnormalities, and pregnancy loss at doses similar to those used in humans

It is a medication that must be regularly injected, gradually increasing in dosage, so it must be prescribed by a health care provider to ensure that the patient is sufficiently educated on the medication, how to administer the medication, and what should be expected while taking the medication
While its primary use is for managing diabetes, it can also support weight loss in individuals who are dealing with related health issues

Probiotics are classified as food supplements in the UK, regulated by the FSA rather than the MHRA, and are not subject to the same rigorous testing as medicines

Generally, the best candidates are women under the age of 60 or within 10 years of menopause onset who have bothersome symptoms, and don't have contraindications to systemic hormone therapy (which include a history of blood clots and certain types of cancer, like breast cancer), according to Faubion
