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Description
Whilst the pathogenesis of PD remains unclear, impaired insulin signaling appears detrimental in the development and progression of PD-related neurodegeneration

Ligand specificity GLP-2 and GLP-1 share high sequence similarity (69.7%) and have almost identical residues in two regions: the N-terminus (first six residues in GLP-2) that penetrates into the TMD core, and the C-terminus (residues 1833) that is recognized by the ECD and ECL1 of the receptor

Treatment Duration 17.12.6

doi: 10.2337/cd19-0079 26 NauckMAStewartMWPerkinsCJones-LeoneAYangFPerryCet al

ANZCA Consensus Statement
