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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: translational difficulties and pitfalls

doi: 10.1021/ja011774y
Inhibiting the release of glucagon by the pancreas

GLP-1 medications are rightly celebrated for their effects on blood sugar and weight

Observational studies further reveal reductions in alcohol, opioid, and cannabis use in real-world populations treated with GLP-1RAs, reinforcing the clinical relevance of GBA signaling in addiction
