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169 Chronic hyperglycemia decreases the complexity and differentiation of 3xTg-AD newborn neurons and depressed synaptic facilitation, accompanied by defective hippocampal-dependent memory, 109 suggesting that diabetes promotes changes in AD neurogenesis that ultimately exacerbates cognitive impairment

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Lepping R.J., Bruce A.S., Francisco A., Yeh H.W., Martin L.E., Powell J.N., Hancock L., Patrician T.M., Breslin F.J., Selim N., et al