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These limitations include relevance of in vitro studies to in vivo impact, as well as specificity to one transporter over another transporter, as transporters such as P-gp and BCRP can have overlapping activities

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She adds, Another important factor to remember is that many of the benefits of these supplements have been studied in the oral doses, but there are limited studies in patch formulations. Risks and side effects of GLP-1 patches Because GLP-1 patches are classified as dietary supplements, theyre not regulated with the same strict standards as prescription medications