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Trials and community sources describe discontinuation when: Resting heart rate is consistently above 100 bpm, insomnia persists beyond one week, or significant anxiety, palpitations, or blood-pressure spikes appear

Room Temperature and Travel: When You Can't Refrigerate Compounded tirzepatide can be kept at room temperature (up to 77F or 25C) for limited periodstypically no longer than 28 days total from the compounding datebut refrigeration is always preferred for maximum stability

Clean, smooth areas like the upper arms or abdomen

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Weeks 824: Gradual improvement