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Validation and characterization of a novel method for selective vagal deafferentation of the gut

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These side effects occur in approximately 10-40% of patients depending on the specific medication and dose, typically appearing during dose initiation or escalation

The least-squares mean percentage change in weight at 48 weeks (secondary endpoint) was 8.7% in the 1-mg group, 16.3% in the 4-mg group with an initial dose of 2 mg, 17.8% in the 4-mg group with an initial dose of 4 mg, 21.7% in the 8-mg group with an initial dose of 2 mg, 23.9% in the 8-mg group with an initial dose of 4 mg, and 24.2% in the 12-mg group with an initial dose of 2 mg, as compared with 2.1% in the placebo group

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