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Here, in this mechanistic secondary analysis of the SUMMIT trial, tirzepatide treatment at 52 weeks, as compared with placebo, reduced systolic blood pressure (estimated treatment difference (ETD) 5 mmHg, 95% confidence interval (CI) 7 to 3

These side effects often decrease over time as your body adjusts to the medication

Solution: track food intake for a few days to objectively assess whether your total caloric consumption has actually changed

Contact your healthcare provider immediately to discuss interim glucose management strategies, which may include temporarily resuming or adjusting other diabetes medications, intensifying glucose monitoring, and implementing dietary modifications until replacement tirzepatide is available

Semaglutide is a GLP-1 receptor agonist, which helps to regulate blood sugar by enhancing insulin secretion, slowing gastric emptying, and promoting satiety