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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (65)

What should I do if travel, illness, or missed doses interrupts the weekly schedule

Your comfort and consistency matter because patients who feel confident with their injection technique tend to stay on treatment longer and see better results

When the food contains sulfur, the problem is exacerbated

2) abnormal state with extracellular water (ECW) such as systemic edema or dehydration