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The approval of semaglutide for chronic weight management has fundamentally changed obesity medicine, and semaglutide training for physicians has become an urgent clinical priority

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What if you start on a low dose of GLP-1s instead

Method We systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes
