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Our results reveal the existence of residue networks crucial for unimolecular agonist-mediated receptor activation and their distinct signaling patterns, which might be useful to the rational design of biased drug leads.

In this attempt, observational and experimental studies and review articles will be gathered from leading scientists in the field of diabetes mellitus.Areas to be covered in this Research Topic may include, but are not limited to:- Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on testosterone and gonadotropins in male patients with diabetes mellitus and hypogonadism- Studies on the effect of SGLT2 inhibitors or GLP-1 receptor agonists on testosterone gonadotropins in female patients with diabetes mellitus and p...

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