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Wednesdays approval is backed by data from the Phase I VOLTAIRE-HCLF study, which compared the bioavailability of the high- and low-concentration (50 mg/mL) formulation of Cyltezo in 200 healthy volunteers

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M2 macrophages are anti-inflammatory, promoting tissue repair and resolution of inflammation

Subsequent cohorts were dosed after the dosing regimen in the preceding cohort was recommended to be safe and well tolerated based on the safety and laboratory data through at least day 15