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doi: 10.1038/ki.2014.236

O diabetes mellitus tipo 2 (DM2) uma doena crnica de grande prevalncia mundial, representando cerca de 90% dos casos de diabetes no Brasil (ANTUNES et al., 2021)

[18] It is also indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adolescents (aged twelve years and older) with obesity and body weight above 60 kg (130 lb)

This highlights the complexity of GPCR activation, where downstream signalling is influenced by the interplay of multiple transducers that can interact with activated receptors (pleiotropic coupling), and can also be influenced by different trafficking profiles that alter the location of the receptor in the cell

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